{"id":8687,"date":"2018-08-04T12:00:06","date_gmt":"2018-08-04T10:00:06","guid":{"rendered":"https:\/\/zdravovek.eu\/?p=8687"},"modified":"2020-09-15T13:36:04","modified_gmt":"2020-09-15T11:36:04","slug":"histamin-funkce","status":"publish","type":"post","link":"https:\/\/zdravovek.eu\/cs\/histamin-funkce\/","title":{"rendered":"Histamin &#8211; jeho d\u016fle\u017eit\u00e9 funkce (je n\u00e1\u0161 nep\u0159\u00edtel?)"},"content":{"rendered":"<p>I vy pat\u0159\u00edte do <strong>skupiny alergik\u016f<\/strong>?<\/p>\n<p>Mo\u017en\u00e1 ka\u017ed\u00e9 jaro doslova p\u0159etrp\u00edte. K\u00fdch\u00e1te, ot\u00e9k\u00e1 v\u00e1m nos, slz\u00ed v\u00e1m o\u010di, ot\u00e9k\u00e1te&#8230; Jednodu\u0161e, jste alergi\u010dt\u00ed na pyly nebo tr\u00e1vy. Alergici na zv\u00ed\u0159ata zas k\u00fdchaj\u00ed, kdy\u017e se v okol\u00ed vyskytne nap\u0159\u00edklad ko\u010dka nebo pes.<\/p>\n<p>Mo\u017en\u00e1 v\u00e1m byla <a href=\"https:\/\/zdravovek.eu\/histaminova-intolerancia\/\">diagnostikov\u00e1na histaminov\u00e1 intolerance<\/a> a probl\u00e9mem je <strong>va\u0161e stravov\u00e1n\u00ed<\/strong>. V\u0161echny tyto nemoci jsou <strong>zp\u016fsobeny histaminem<\/strong> a my si o n\u011bm nyn\u00ed nap\u00ed\u0161eme v\u00edce.<\/p>\n\n<h2>Co je to histamin?<\/h2>\n<p>Histamin je chemick\u00fd <strong>neurotransmiter<\/strong>, kter\u00fd se vyskytuje<strong>\u00a0v na\u0161em t\u011ble<\/strong> <strong>p\u0159irozen\u011b\u00a0<\/strong>a je v n\u011bm skladov\u00e1n. Tvo\u0159\u00ed ho <strong>mastocyty<\/strong> (jin\u00fd n\u00e1zev je \u017e\u00edrn\u00e9 bu\u0148ky). Chemicky je histamin <strong>proteinov\u00e1 molekula<\/strong> se souhrnn\u00fdm chemick\u00fdm vzorcem C5H9N3.<\/p>\n<p>Histamin tvo\u0159\u00ed v\u00fdznamnou sou\u010d\u00e1st na\u0161\u00ed imunitn\u00ed odpov\u011bdi.<\/p>\n<p>Pokud se n\u00e1\u0161 organismus dostane do situace, v n\u00ed\u017e se setk\u00e1 s alergenem, histamin se <strong>uvoln\u00ed z mastocyt\u016f<\/strong>. C\u00edlem uvoln\u011bn\u00ed histaminu je <strong>zm\u00edrn\u011bn\u00ed podr\u00e1\u017ed\u011bn\u00ed<\/strong>, kter\u00e9 vyvol\u00e1 alergen.<\/p>\n<p>Paradoxem tedy je, \u017ee i <strong>samotn\u00e9 p\u0159\u00edznaky alergie jsou zp\u016fsobeny histaminem<\/strong>. Jeho \u00fa\u010dinek v n\u011bkter\u00fdch p\u0159\u00edpadech m\u016f\u017ee b\u00fdt dokonce <strong>smrteln\u00fd<\/strong>. Je to tehdy, kdy\u017e dojde k takzvan\u00e9mu <strong>anafylaktick\u00e9mu \u0161oku<\/strong> p\u0159i siln\u00fdch alergick\u00fdch reakc\u00edch.<\/p>\n<h2>Vznik histaminu<\/h2>\n<p>Histamin je <strong>syntetizov\u00e1n n\u011bkolika bu\u0148kami<\/strong>. Jsou to tyto:<\/p>\n<ul>\n<li>mastocyty<\/li>\n<li>bazofily<\/li>\n<li>krevn\u00ed desti\u010dky<\/li>\n<li>histaminergn\u00e9 neurony<\/li>\n<li>enterochromafinn\u00e9 bu\u0148ky<\/li>\n<\/ul>\n<p>Je <strong>tvo\u0159en z aminokyseliny histidinu<\/strong> p\u0159es enzym L-histid\u00edndekarboxyl\u00e1za. Aktivita tohoto enzymu je z\u00e1visl\u00e1 na\u00a0<strong>vitam\u00ednu B6<\/strong>.<\/p>\n<h2>Histaminov\u00e9 receptory<\/h2>\n<p>V na\u0161em organismu se nach\u00e1zej\u00ed <strong>\u010dty\u0159i typy histaminov\u00fdch receptor\u016f<\/strong>. Nejd\u016fle\u017eit\u011bj\u0161\u00ed z nich je histaminov\u00fd receptor 1, ve zkratce H1. Pr\u00e1v\u011b <strong>H1<\/strong> se pod\u00edl\u00ed na alergick\u00fdch reakc\u00edch v na\u0161em t\u011ble.<\/p>\n<figure id=\"attachment_11335\" aria-describedby=\"caption-attachment-11335\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" class=\"wp-image-11335 size-large\" src=\"https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-1024x750.jpg\" alt=\"Histaminov\u00e9 receptory\" width=\"1024\" height=\"750\" srcset=\"https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-1024x750.jpg 1024w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-600x439.jpg 600w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-300x220.jpg 300w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-768x562.jpg 768w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-80x60.jpg 80w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-696x509.jpg 696w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-1068x782.jpg 1068w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-574x420.jpg 574w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory.jpg 1280w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption id=\"caption-attachment-11335\" class=\"wp-caption-text\">Zdroj: 123rf.com<\/figcaption><\/figure>\n<p>Po nav\u00e1z\u00e1n\u00ed se na tento receptor m\u00e1 histamin i jin\u00e9 \u00fa\u010dinky. Reguluje na\u0161e vnit\u0159n\u00ed hodiny, c\u00edt\u00edte se bd\u011blej\u0161\u00ed a aktivn\u011bj\u0161\u00ed. Ostatn\u00ed t\u0159i receptory ovliv\u0148uj\u00ed na\u0161e <strong>tr\u00e1ven\u00ed<\/strong>, vylu\u010dov\u00e1n\u00ed \u017ealude\u010dn\u00ed kyseliny ale i n\u011bkter\u00e9 <strong>neurologick\u00e9 funkce<\/strong>.<\/p>\n<div class=\"erit-block erit-block-tip\">\n<p>Pokud v\u00e1s zaj\u00edmaj\u00ed \u00fa\u010dinky konkr\u00e9tn\u00edch histaminov\u00fdch receptor\u016f a <a href=\"https:\/\/zdravovek.eu\/antihistaminika\/\"><strong>jak p\u016fsob\u00ed antihistaminika<\/strong>, p\u0159e\u010dt\u011bte si \u010dl\u00e1nek<\/a>.<\/p>\n<\/div>\n<h2>Funkce histaminu<\/h2>\n<p>Histamin je komplexn\u00ed molekula, kter\u00e1 <strong>ovliv\u0148uje \u0159adu biologick\u00fdch proces\u016f<\/strong>.<\/p>\n<p>Ka\u017ed\u00fd \u00fa\u010dinek a \u00falohu histaminu si pop\u00ed\u0161eme n\u00ed\u017ee:<\/p>\n<h3>Alergick\u00e9 reakce<\/h3>\n<p>Na to, abychom pochopili roli histaminu v na\u0161em organismu, mus\u00edme <strong>l\u00e9pe porozum\u011bt alergick\u00fdm reakc\u00edm<\/strong> jako takov\u00fdm.<\/p>\n<p>Pop\u00ed\u0161eme si b\u011b\u017enou alergii, se kterou jsem se potr\u00e1pila poprv\u00e9 v \u017eivot\u011b letos i j\u00e1. Je to alergie na pyl. <strong>Pyl<\/strong> se dostane p\u0159es nos a \u00fasta do t\u011bla. Imunitn\u00ed syst\u00e9m ho <strong>vyhodnot\u00ed jako ciz\u00ed t\u011bleso<\/strong> a proto proti n\u011bmu za\u010dne bojovat. C\u00edlem organismu je ciz\u00ed t\u011bleso co nejrychleji <strong>odstranit<\/strong> a proto se <strong>vylu\u010duje histamin<\/strong>.<\/p>\n<p>Nav\u00edc, organismus jako obrannou reakci proti vysok\u00fdm hladin\u00e1m histaminu za\u010dne <strong>produkovat adrenalin<\/strong>. Proto jsou u pacient\u016f v dob\u011b siln\u00e9 alergie nebo anafylaxe b\u011b\u017en\u00e9 stavy <a href=\"https:\/\/zdravovek.eu\/cs\/uzkost\/\"><strong>\u00fazkosti a paniky<\/strong><\/a>.<\/p>\n<p>Histamin se tedy uvoln\u00ed a funguje jako posel. Putuje na <strong>m\u00edsto podr\u00e1\u017ed\u011bn\u00ed<\/strong> aby aktivoval adekv\u00e1tn\u00ed odpov\u011b\u010f organismu. Nav\u00e1\u017ee se na ur\u010dit\u00e9 \u010d\u00e1sti receptor\u016f, \u010d\u00edm\u017e doch\u00e1z\u00ed k vyvol\u00e1n\u00ed specifick\u00fdch p\u0159\u00edznak\u016f &#8211; nap\u0159\u00edklad <strong>zv\u00fd\u0161en\u00ed sekrece z nosu<\/strong>. Intenzita p\u0159\u00edznak\u016f je jin\u00e1 u ka\u017ed\u00e9ho a z\u00e1vis\u00ed na mno\u017estv\u00ed histaminu, kter\u00e9 se uvoln\u00ed.<\/p>\n<span class=\"erit-highlight\"> A co p\u0159esn\u011b histamin v alergick\u00fdch reakc\u00edch zp\u016fsob\u00ed? <\/span>\n<ul>\n<li><strong>Vazodilatace<\/strong> (roz\u0161\u00ed\u0159en\u00ed c\u00e9v). Doch\u00e1z\u00ed k n\u00ed tehdy, kdy\u017e se sval, kter\u00fd se nach\u00e1z\u00ed v c\u00e9v\u011b uvoln\u00ed a vnit\u0159ek c\u00e9vy se roz\u0161\u00ed\u0159\u00ed. C\u00edl vazodilatace je jednoduch\u00fd &#8211; v roz\u0161\u00ed\u0159en\u00fdch c\u00e9v\u00e1ch <strong>snadn\u011bji putuj\u00ed b\u00edl\u00e9 krvinky<\/strong>, kter\u00e9 pom\u00e1haj\u00ed imunitn\u00edm obrann\u00fdm mechanismem t\u011bla.<\/li>\n<li><strong>Zv\u00fd\u0161en\u00ed sekrece v m\u00edst\u011b z\u00e1n\u011btu\/reakce<\/strong>. Projev\u00ed se to jako otekl\u00fd nos, sekret z nosu, sv\u011bd\u00edc\u00ed o\u010di, otok v m\u00edst\u011b kousnut\u00ed a podobn\u011b. Zv\u00fd\u0161en\u00e1 sekrece je efektivn\u00ed proto, \u017ee zv\u00fd\u0161en\u00fdm sekretem (slzy, v\u00fdtok z nosu) se vylu\u010duj\u00ed alergeny, kter\u00e9 n\u00e1s dr\u00e1\u017ed\u00ed.<\/li>\n<li>Histamin ovliv\u0148uje <strong>aktivitu makrof\u00e1g\u016f a pomocn\u00fdch T-bun\u011bk<\/strong>. Ovlivn\u011bna je tedy i produkce protil\u00e1tek.<\/li>\n<\/ul>\n<h3>Imunita<\/h3>\n<p>Histamin nen\u00ed aktivn\u00ed pouze v akutn\u00ed f\u00e1zi imunity a p\u0159i hypersenzitivn\u00edch reakc\u00edch. Tvo\u0159\u00ed tak\u00e9 <strong>sou\u010d\u00e1st dlouhodob\u00e9 imunity<\/strong> a je aktivn\u00ed p\u0159i chronick\u00fdch z\u00e1n\u011btech. Dok\u00e1\u017ee ovlivnit n\u011bkolik imunitn\u00edch bun\u011bk. Konkr\u00e9tn\u011b jsou to makrof\u00e1gy, dendrick\u00e9 bu\u0148ky, T a B lymfocyty a bu\u0148ky endotelu. Tyto bu\u0148ky p\u016fsob\u00ed na histaminov\u00e9 receptory a c\u00edlen\u011b zvy\u0161uj\u00ed produkci histaminu. Histamin reguluje i Th1 a Th2 bu\u0148ky, kter\u00e9 jsou sou\u010d\u00e1st\u00ed <strong>specifick\u00e9 imunitn\u00ed odpov\u011bdi<\/strong>.<\/p>\n<h3>Histamin jako neurotransmiter<\/h3>\n<p>Neurotransmiter je chemick\u00e1 molekula, kter\u00e1 slou\u017e\u00ed jako <strong>sign\u00e1l mezi neuronem a nervov\u00fdm syst\u00e9mem<\/strong>. Funguje to tak, \u017ee neuron uvoln\u00ed neurotransmiter, neurotransmiter opou\u0161t\u00ed presynaptickou \u010d\u00e1st nervu, proch\u00e1z\u00ed synaps\u00ed a\u017e se dostane k receptoru na druh\u00e9m neuronu, kter\u00fd obsad\u00ed a t\u00edm vyvol\u00e1 reakci. Stimulace neuronu vyvol\u00e1 <strong>r\u016fzn\u00fd typ aktivity v r\u016fzn\u00e9 intenzit\u011b<\/strong>.<\/p>\n<p>Histamin se \u0159ad\u00ed do skupiny <strong>mal\u00fdch molekul<\/strong> neurotransmiter\u016f. V t\u00e9to skupin\u011b se nach\u00e1z\u00ed nap\u0159\u00edklad serotonin, adrenalin nebo dopamin.<\/p>\n<h3>Histamin a \u017ealudek<\/h3>\n<p>Histamin <strong>reguluje koncentraci \u017ealude\u010dn\u00edch \u0161\u0165\u00e1v<\/strong> p\u0159es H2 receptor. Ty napom\u00e1haj\u00ed tr\u00e1ven\u00ed potravy v \u017ealudku. Nejzn\u00e1m\u011bj\u0161\u00ed \u017ealude\u010dn\u00ed \u0161\u0165\u00e1va je kyselina chlorovod\u00edkov\u00e1 (HCl), kter\u00e1 je produkov\u00e1na pariet\u00e1ln\u00edmi bu\u0148kami. HCl je <strong>siln\u011b kysel\u00e1<\/strong>, jej\u00ed pH se pohybuje v oblasti 0,8.<\/p>\n<p><strong>Blok\u00e1tory H2 receptor\u016f<\/strong> se pou\u017e\u00edvaj\u00ed p\u0159i <a href=\"https:\/\/zdravovek.eu\/cs\/zaludecni-vredy\/\">v\u0159edov\u00e9 chorob\u011b \u017ealudku<\/a> a <a href=\"https:\/\/zdravovek.eu\/cs\/paleni-zahy\/\">p\u00e1len\u00ed \u017e\u00e1hy<\/a>. Pat\u0159\u00ed tam l\u00e9ky jako ranitidin a famotidinu (<a href=\"http:\/\/www.vivo.colostate.edu\/hbooks\/pathphys\/digestion\/stomach\/parietal.html\" target=\"_blank\" rel=\"noopener noreferrer\">vivo.colostate.edu<\/a>).<\/p>\n<h3>Histamin a sp\u00e1nek<\/h3>\n<p>Hladina histaminu v ob\u011bhu je regulov\u00e1na <strong>za \u00fa\u010delem fungov\u00e1n\u00ed na\u0161ich vnit\u0159n\u00edch hodin<\/strong> a udr\u017eov\u00e1n\u00ed rovnov\u00e1hy. N\u00e1\u0161 organismus je tedy udr\u017eov\u00e1n v bd\u011bl\u00e9m stavu a aktivit\u011b. Pr\u00e1v\u011b proto je jedn\u00edm z vedlej\u0161\u00edch \u00fa\u010dink\u016f l\u00e9\u010dby <strong>antihistaminiky<\/strong> pr\u00e1v\u011b <strong>ospalost a otup\u011blost<\/strong>.<\/p>\n<h2>Metabolismus histaminu &#8211; odbour\u00e1v\u00e1n\u00ed<\/h2>\n<p><strong>\u017divot<\/strong> histaminu (odborn\u011b polo\u010das) je <strong>dosti kr\u00e1tk\u00fd<\/strong>.<\/p>\n<p>Metabolizuje se dv\u011bma hlavn\u00edmi cestami:<\/p>\n<ul>\n<li>Oxidativn\u00ed deaminace <strong>p\u0159es enzym diaminooxid\u00e1za (DAO)<\/strong>.<br \/>\nDAO se \u010din\u00ed hlavn\u011b p\u0159i metabolizaci extracelul\u00e1rn\u00edho histaminu (<strong>histaminu mimo bu\u0148ky<\/strong>). Uvoln\u00ed se nap\u0159\u00edklad po konzumaci potraviny bohat\u00e9 na histamin. DAO se vyskytuje zejm\u00e9na <strong>v oblasti st\u0159eva, ale i v ledvin\u00e1ch a placent\u011b<\/strong>. Jak jsme se ji\u017e zm\u00ednili v n\u011bkolika \u010dl\u00e1nc\u00edch, hladina DAO je p\u0159i <strong>HIT sn\u00ed\u017eena<\/strong>. DAO se d\u00e1 i suplementovat, nap\u0159\u00edklad <a href='https:\/\/zdravovek.eu\/a\/cs\/daosin-30-tobolek-pilulka-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">potravinov\u00fdm dopl\u0148kem Daosin<\/a>. Podrobn\u011bji si o n\u011bm p\u0159e\u010dtete v <a href=\"https:\/\/zdravovek.eu\/daosin\/\">recenzi na tento p\u0159\u00edpravek<\/a>.<\/li>\n<li>Metylac\u00ed <strong>histamin-N-methyltransfer\u00e1zy (HNMT)<\/strong>.<br \/>\nHNMT m\u00e1 vy\u0161\u0161\u00ed afinitu k histaminu ne\u017e DAO. To znamen\u00e1, \u017ee <strong>snadn\u011bji zpracov\u00e1v\u00e1 histamin<\/strong>. Av\u0161ak dok\u00e1\u017ee ho zpracovat jen intracelul\u00e1rn\u011b (<strong>uvnit\u0159 bu\u0148ky<\/strong>). Tyto dva enzymy spolu tedy nebojuj\u00ed, nebo\u0165 ka\u017ed\u00fd m\u00e1 vlastn\u00ed funkci a jejich \u00fa\u010dinek se nep\u0159ekr\u00fdv\u00e1. HNMT se nach\u00e1z\u00ed <strong>skoro v ka\u017ed\u00e9 tk\u00e1ni<\/strong>, nejv\u00edce ho je v ledvin\u011b, j\u00e1trech, slezin\u011b, st\u0159ev\u011b, prostat\u011b, vaje\u010dn\u00edc\u00edch, p\u00e1te\u0159i a v okol\u00ed pr\u016fdu\u0161ek.<\/li>\n<\/ul>\n<div class='erit-cta-block '>\n\n                <a class='erit-cta-block-button eap_conversion cta_block cta_button mobile_only' href='https:\/\/zdravovek.eu\/a\/cs\/daosin-30-tobolek-pilulka-cz\/' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_cta_block', 'EAP_click_cta_button', null)\">\n                  <img src='https:\/\/zdravovek.eu\/wp-content\/plugins\/erit-affil-publisher\/img\/info-eap.png' alt='icon' class='erit-cta-block-button-icon eap-icon' \/>Zjistit v\u00edce\n                <\/a>\n                \n                <div class='erit-cta-block-content'><strong><a href='https:\/\/zdravovek.eu\/a\/cs\/daosin-30-tobolek-pilulka-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">DAOSIN<\/a> 30 kapsl\u00ed<\/strong><\/p>\n<ul>\n<li>pr\u00e1v\u011b v p\u0159\u00edpad\u011b histaminov\u00e9 intolerance je v t\u011ble <strong>nedostatek enzymu DAO<\/strong><\/li>\n<li>Daosin obsahuje <strong>p\u0159irozen\u00fd enzym<\/strong> diaminooxid\u00e1za<\/li>\n<li>neobsahuje lepek ani lakt\u00f3zu<\/li>\n<li>p\u0159e\u010dt\u011bte si o n\u011bm <a href=\"https:\/\/zdravovek.eu\/daosin\/\">v\u00edce v recenzi<\/a><\/li>\n<\/ul>\n<\/div>\n                \n                <div class='erit-cta-block-img-wrap'>\n                    <a class='product-image eap_conversion cta_block image' href='https:\/\/zdravovek.eu\/a\/cs\/daosin-30-tobolek-pilulka-cz\/' rel='nofollow' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_cta_block', 'EAP_click_image', null)\"><img width='150' src='https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/03\/daosin.png' alt='DAOSIN' \/><\/a>\n                    \n                    <a class='erit-cta-block-button eap_conversion cta_block cta_button' href='https:\/\/zdravovek.eu\/a\/cs\/daosin-30-tobolek-pilulka-cz\/' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_cta_block', 'EAP_click_cta_button', null)\">\n                      <img src='https:\/\/zdravovek.eu\/wp-content\/plugins\/erit-affil-publisher\/img\/info-eap.png' alt='icon' class='erit-cta-block-button-icon eap-icon' \/>Zjistit v\u00edce\n                     <\/a>\n                    \n                <\/div>\n              <\/div>\n<h2>Z\u00e1v\u011br<\/h2>\n<p>Pokud jste pozorn\u011b \u010detli n\u00e1\u0161 \u010dl\u00e1nek zjistili jste, co je histamin. Ur\u010dit\u011b u\u017e v\u00edte, \u017ee je <strong>velmi d\u016fle\u017eit\u00e1 molekula<\/strong>. Ned\u00e1 se \u0159\u00edci, \u017ee je pro n\u00e1s jen \u0161kodliv\u00fd. V mnoha oblastech n\u00e1m vysloven\u011b usnad\u0148uje \u017eivot.<\/p>\n<p>Probl\u00e9m s histaminem nast\u00e1v\u00e1 a\u017e tehdy, kdy\u017e je jeho <strong>hladina vy\u0161\u0161\u00ed ne\u017e bychom pot\u0159ebovali<\/strong>. Tak\u00e9 jste se dozv\u011bd\u011bli o dvou <strong>enzymech<\/strong>, kter\u00e9 histamin rozkl\u00e1daj\u00ed a jak\u00e9 m\u00e1 n\u00e1sledky jejich nedostatek.<\/p>\n<p><strong>Zdroje<\/strong>:<\/p>\n<ul>\n<li><a href=\"https:\/\/study.com\/academy\/lesson\/histamine-definition-effects-role.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">study.com<\/a><\/li>\n<li><a href=\"http:\/\/sepa.duq.edu\/regmed\/immune\/histamine.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">sepa.duq.edu<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16354958\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">ncbi.nlm.nih.gov<\/a><\/li>\n<li><a href=\"http:\/\/www.solen.sk\/pdf\/d62980fe4ce2836711fb683c1fc18348.pdf\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">solen.sk<\/a><\/li>\n<li><a href=\"https:\/\/histaminovaintolerancia.sk\/metabolizmus-histaminu\/\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">histaminovaintolerancia.sk<\/a><\/li>\n<\/ul>\n<div class='erit-disclaimer'><span class='erit-disclaimer-icon'><span class='erit-disclaimer-text'>!<\/span><\/span><span class='erit-disclaimer-text'>\u010cl\u00e1nek byl vypracov\u00e1n l\u00e9k\u00e1rn\u00edkem av\u0161ak, slou\u017e\u00ed pouze pro informativn\u00ed \u00fa\u010dely - nenahrazuje l\u00e9ka\u0159sk\u00e9 vy\u0161et\u0159en\u00ed, nebo osobn\u00ed setk\u00e1n\u00ed v l\u00e9k\u00e1rn\u011b.<\/span><\/div>\n<script type='text\/javascript' >\n                jQuery(document).ready(function($) {\n    \n                    let data = {\n                        'action': 'render_widget_action',\n                        'postId': null,\n                        'categoryId': null\n                    };\n    \n                    let ajaxUrlFromPHP = 'https:\/\/zdravovek.eu\/wp-admin\/admin-ajax.php';\n                    jQuery.post(ajaxUrlFromPHP, data, function(response) {\n                        if(response == 0){\n                            \/\/ chyba\n                            jQuery( '#eap_top_w' ).html( '' );\n                            jQuery( '#eap_top_w_wrap' ).hide();\n                        } if(response == -1){\n                            \/\/ nenasli ziadne produkty\n                            jQuery( '#eap_top_w' ).html( '' );\n                            jQuery( '#eap_top_w_wrap' ).hide();\n                        } else {\n                            let desktop = $(window).width() > 960;\n                            if(desktop){\n                                jQuery( '#eap_top_w' ).html( response );\n                                jQuery( '#eap_top_w_wrap' ).fadeIn(1000);\n                            } else {\n                                jQuery( '#eap_top_w_mob_chart' ).html( response );\n                                jQuery( '#eap_top_w_mob' ).fadeIn(1000); 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Mo\u017en\u00e1 ka\u017ed\u00e9 jaro doslova p\u0159etrp\u00edte. K\u00fdch\u00e1te, ot\u00e9k\u00e1 v\u00e1m nos, slz\u00ed v\u00e1m o\u010di, ot\u00e9k\u00e1te&#8230; Jednodu\u0161e, jste alergi\u010dt\u00ed na pyly nebo tr\u00e1vy. Alergici na zv\u00ed\u0159ata zas k\u00fdchaj\u00ed, kdy\u017e se v okol\u00ed vyskytne nap\u0159\u00edklad ko\u010dka nebo pes. Mo\u017en\u00e1 v\u00e1m byla diagnostikov\u00e1na histaminov\u00e1 intolerance a probl\u00e9mem je va\u0161e stravov\u00e1n\u00ed. V\u0161echny tyto nemoci jsou [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":10174,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[81,79],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Histamin - d\u016fle\u017eit\u00e9 funkce (je n\u00e1\u0161 nep\u0159\u00edtel?) | Zdravov\u011bk<\/title>\n<meta name=\"description\" content=\"HISTAMIN - p\u0159\u00ed\u010dina alergi\u00ed, nebo n\u00e1\u0161 dobr\u00fd spojenec? Histamin je pro n\u00e1s nesm\u00edrn\u011b d\u016fle\u017eit\u00fd. 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