{"id":7954,"date":"2018-07-27T10:21:04","date_gmt":"2018-07-27T08:21:04","guid":{"rendered":"https:\/\/zdravovek.eu\/?p=7954"},"modified":"2020-09-15T18:48:42","modified_gmt":"2020-09-15T16:48:42","slug":"antihistaminika","status":"publish","type":"post","link":"https:\/\/zdravovek.eu\/cs\/antihistaminika\/","title":{"rendered":"Antihistaminika &#8211; jak\u00e9 druhy zn\u00e1me, jejich \u00fa\u010dinky, pou\u017eit\u00ed"},"content":{"rendered":"<p>Antihistaminika jsou l\u00e9ky, kter\u00e9 si v\u011bt\u0161inou spojujeme v souvislosti s alergi\u00ed.<\/p>\n<p>Ale v\u00edte, <strong>na co v\u0161echno<\/strong> se je\u0161t\u011b mohou <strong>vyu\u017e\u00edt<\/strong>?<\/p>\n<p>Zn\u00e1me n\u011bkolik druh\u016f, kter\u00e9 mohou fungovat rozd\u00edln\u011b &#8211; podle toho, na jak\u00fd histaminov\u00fd receptor se v\u00e1\u017eou. Sepsali jsme <strong>seznam\u00a0antihistaminik<\/strong>, podle toho, do kter\u00e9 generace pat\u0159\u00ed + kter\u00e1 antihistaminika dostanete <strong>bez p\u0159edpisu<\/strong>.<\/p>\n<p>Zjist\u00edte tak\u00e9, kter\u00e9 <strong>p\u0159\u00edrodn\u00ed l\u00e1tky<\/strong> by mohly plnit funkci antihistaminik.<\/p>\n\n<h2>Co jsou to antihistaminika?<\/h2>\n<p>Antihistaminika jsou l\u00e9ky, kter\u00e9 <strong>blokuj\u00ed vazbu histaminu<\/strong> na histaminov\u00e9 receptory (a t\u00edm blokuj\u00ed projeven\u00ed jeho \u00fa\u010dink\u016f).<\/p>\n<p>Jsou v\u011bt\u0161inou pou\u017e\u00edv\u00e1ny k <strong>l\u00e9\u010db\u011b alergi\u00ed<\/strong> nebo zm\u00edrn\u011bn\u00ed symptom\u016f <strong>nachlazen\u00ed a ch\u0159ipky<\/strong>. N\u011bkter\u00e1 antihistaminika prvn\u00ed generace mohou b\u00fdt pou\u017eita i na jin\u00e9 chorobn\u00e9 stavy.<\/p>\n<p>Histaminov\u00e9 <strong>receptory<\/strong> se nach\u00e1zej\u00ed <strong>v r\u016fzn\u00fdch \u010d\u00e1stech t\u011bla<\/strong>. Jsou p\u0159\u00edtomny v d\u00fdchac\u00edch cest\u00e1ch, c\u00e9v\u00e1ch, srdci a tr\u00e1vic\u00edm traktu. Nach\u00e1zej\u00ed se tak\u00e9 v mozku a m\u00ed\u0161e.<\/p>\n<h2>Na co se pou\u017e\u00edvaj\u00ed antihistaminika?<\/h2>\n<p>Antihistaminika jsou \u0161iroce vyu\u017e\u00edvan\u00e9 l\u00e9ky.<\/p>\n<p>Pou\u017e\u00edvaj\u00ed se hlavn\u011b p\u0159i <strong>zm\u00edr\u0148ov\u00e1n\u00ed p\u0159\u00edznak\u016f alergick\u00e9 reakce<\/strong>, jako jsou:<\/p>\n<ul>\n<li>otok<\/li>\n<li>z\u00e1n\u011bt<\/li>\n<li>sv\u011bd\u011bn\u00ed<\/li>\n<li>vyr\u00e1\u017eky<\/li>\n<li>zarudl\u00e9 o\u010di se sklonem k slzen\u00ed<\/li>\n<li>nadm\u011brn\u00fd v\u00fdtok z nosu<\/li>\n<li>k\u00fdch\u00e1n\u00ed<\/li>\n<\/ul>\n<p>D\u00edky tomu jsou antihistaminika velmi \u00fa\u010dinn\u00e1 i <strong>p\u0159i l\u00e9\u010db\u011b onemocn\u011bn\u00ed<\/strong> jako:<\/p>\n<ul>\n<li><strong>alergick\u00e1 r\u00fdma<\/strong>\u00a0a konjunktivitida (z\u00e1n\u011bt spojivek)<\/li>\n<li>nachlazen\u00ed a ch\u0159ipka<\/li>\n<li><a href=\"https:\/\/zdravovek.eu\/cs\/potravinova-intolerance\/\"><strong>potravinov\u00e9 alergie<\/strong><\/a><\/li>\n<li>ko\u017en\u00ed alergick\u00e9 projevy a <a href=\"https:\/\/zdravovek.eu\/cs\/ekzem\/\"><strong>ekz\u00e9m<\/strong><\/a><\/li>\n<li>senn\u00e1 r\u00fdma<\/li>\n<li>reakce z p\u0159ecitliv\u011blosti na l\u00e9ky<\/li>\n<li><a href=\"https:\/\/zdravovek.eu\/ustipnutie-osou-vcelou-kliestom-hmyzom\/\"><strong>\u0161t\u00edpnut\u00ed hmyzem<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/zdravovek.eu\/cs\/histaminova-intolerance\/\"><strong>histaminov\u00e1 intolerance<\/strong><\/a><\/li>\n<\/ul>\n<h3>Antihistaminika 1. generace<\/h3>\n<p>Antihistaminika 1. generace p\u016fsob\u00ed i v CNS (mozku a m\u00ed\u0161e).<\/p>\n<p>N\u011bkter\u00e1 z nich jsou proto pou\u017e\u00edv\u00e1na i na:<\/p>\n<ul>\n<li><a href=\"https:\/\/zdravovek.eu\/cs\/prasky-na-spani-bez-predpisu\/\"><strong>navozen\u00ed sp\u00e1nku<\/strong><\/a> (sedativn\u00ed \u00fa\u010dinek)<\/li>\n<li>prevenci nebo l\u00e9\u010dbu <strong>kinet\u00f3z<\/strong> (nevolnost z pohybu &#8211; nap\u0159. p\u0159i cestov\u00e1n\u00ed lod\u00ed, autobusem&#8230;)<\/li>\n<li>redukuj\u00ed <strong>nevolnost a zvracen\u00ed<\/strong> (antiemetika)<\/li>\n<li><a href=\"https:\/\/zdravovek.eu\/cs\/uzkost-lecba\/\"><strong>redukuj\u00ed \u00fazkost<\/strong><\/a> (anxiolytika)<\/li>\n<li>jsou n\u00e1pomocn\u00e1 u lid\u00ed s <strong>Parkinsonovou chorobou<\/strong> (zdroj: <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1471-4159.2002.00871.x\" target=\"_blank\" rel=\"noopener noreferrer\">onlinelibrary<\/a>)<\/li>\n<\/ul>\n<h2>Druhy antihistaminik<\/h2>\n<p>Antihistaminika lze rozd\u011blit do 3 hlavn\u00edch kategori\u00ed:<\/p>\n<ul>\n<li>antihistaminika <strong>1. generace<\/strong> (sedativn\u00ed &#8211; p\u0159ech\u00e1zej\u00ed do CNS)<\/li>\n<li>antihistaminika <strong>2. generace<\/strong> (nesedativn\u00ed &#8211; minim\u00e1ln\u00ed pr\u016fchod do CNS, nemaj\u00ed \u017e\u00e1dn\u00e9 sedativn\u00ed \u00fa\u010dinky v doporu\u010den\u00fdch d\u00e1vk\u00e1ch)<\/li>\n<li>antihistaminika <strong>3. generace<\/strong> (nesedativn\u00ed, \u2191 \u00fa\u010dinek)<\/li>\n<\/ul>\n<h3>Antihistaminika prvn\u00ed generace<\/h3>\n<p>Byla vyvinuta p\u0159ed v\u00edce ne\u017e 70 lety, ale dnes jsou st\u00e1le roz\u0161\u00ed\u0159en\u00e1. Ovliv\u0148uj\u00ed histaminov\u00e9 receptory v mozku a m\u00ed\u0161e a ve zbytku t\u011bla (na tzv. Periferii).<\/p>\n<p>Krom\u011b histaminov\u00fdch receptor\u016f p\u016fsob\u00ed i na jin\u00e9 typy receptor\u016f (muskarinov\u00e9, alfa-adrenergn\u00ed a serotoninov\u00e9). To znamen\u00e1, \u017ee p\u0159i u\u017eit\u00ed antihistaminik prvn\u00ed generace se mohou vyskytnout <strong>vedlej\u0161\u00ed \u00fa\u010dinky<\/strong>, jako je sedace, sucho v \u00fastech, z\u00e1vrat\u011b, n\u00edzk\u00fd krevn\u00ed tlak \u010di zrychlen\u00fd srde\u010dn\u00ed rytmus.<\/p>\n<p><strong>Interakce<\/strong> s jin\u00fdmi l\u00e9ky jsou b\u011b\u017en\u011bj\u0161\u00ed u antihistaminik 1. generace ve srovn\u00e1n\u00ed s antihistaminiky 2. generace.<\/p>\n<h3>Antihistaminika druh\u00e9 generace<\/h3>\n<p>Druh\u00e1 generace antihistaminik byla vyvinuta v 80. letech minul\u00e9ho stolet\u00ed. Ty, co sem pat\u0159\u00ed, maj\u00ed mnohem men\u0161\u00ed vliv na sedaci, ne\u017e antihistaminika prvn\u00ed generace.<\/p>\n<p>P\u016fsob\u00ed na H1 histaminov\u00e9 receptory na periferii a je nepravd\u011bpodobn\u00e9, \u017ee proniknou do mozku. Kv\u016fli tomu se u nich m\u00e9n\u011b \u010dasto vyskytuj\u00ed vedlej\u0161\u00ed \u00fa\u010dinky.<\/p>\n<p>Tak\u00e9 se m\u00e9n\u011b vz\u00e1jemn\u011b ovliv\u0148uj\u00ed s jin\u00fdmi l\u00e9ky (i kdy\u017e jsou mo\u017en\u00e9 interakce s inhibitory CYP 450). V\u011bt\u0161ina antihistaminik druh\u00e9 generace <strong>nezp\u016fsobuje ospalost<\/strong>, i kdy\u017e n\u011bkter\u00e9 (nap\u0159\u00edklad cetirizin a fexofenadin) ji mohou zp\u016fsobit ve vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch (p\u0159i p\u0159ed\u00e1vkov\u00e1n\u00ed).<\/p>\n<p>Maj\u00ed i dal\u0161\u00ed pozitivn\u00ed \u00fa\u010dinky &#8211; p\u016fsob\u00ed protiz\u00e1n\u011btliv\u011b.<\/p>\n<h3>Antihistaminika t\u0159et\u00ed generace<\/h3>\n<p>3. generace byla vyvinuta kv\u016fli dosa\u017een\u00ed je\u0161t\u011b lep\u0161\u00edch \u00fa\u010dink\u016f. U t\u011bchto l\u00e9k\u016f jsou zachov\u00e1na pozitiva a z\u00e1rove\u0148 odstran\u011bny nedostatky 2. generace antihistaminik.<\/p>\n<p>Kv\u016fli tomu, \u017ee nejsou metabolizov\u00e1ny v j\u00e1trech se dos\u00e1hlo i <strong>sn\u00ed\u017een\u00e9ho rizika inerakc\u00ed<\/strong>\u00a0s jin\u00fdmi l\u00e9ky. Ani v p\u0159\u00edpad\u011b vy\u0161\u0161\u00edch d\u00e1vek u nich nejsou pozorov\u00e1ny sedativn\u00ed \u00fa\u010dinky. Maj\u00ed tak\u00e9 vy\u0161\u0161\u00ed selektivitu v\u016f\u010di H1 receptor\u016fm. Vyu\u017e\u00edvaj\u00ed se k odstran\u011bn\u00ed nep\u0159\u00edjemnost\u00ed spojen\u00fdch s alergiemi, jak\u00fdmi je nap\u0159\u00edklad ucpan\u00fd nos.<\/p>\n<h3>Co z toho plyne?<\/h3>\n<p>Klasick\u00e1 antihistaminika (antagonist\u00e9 H1 histaminov\u00e9ho receptoru), kter\u00e1 proch\u00e1zej\u00ed p\u0159es hematoencefalickou bari\u00e9ru (p\u0159ech\u00e1zej\u00ed do mozku), zp\u016fsobuj\u00ed ospalost. Nov\u011bj\u0161\u00ed antihistaminika (2. a 3. generace) jsou navr\u017eena tak, aby neproch\u00e1zela do mozku, a proto je m\u00e9n\u011b pravd\u011bpodobn\u00e9, \u017ee zp\u016fsob\u00ed sedaci a \u00fatlum.<\/p>\n<span class=\"erit-highlight\"> Antihistaminika nezabra\u0148uj\u00ed tvorb\u011b histaminu, ani se nestaraj\u00ed o jeho rozlo\u017een\u00ed. Jejich funkc\u00ed je zabr\u00e1nit vazb\u011b histaminu na jeho receptory (H1 a H2 receptory). <\/span>\n<p>Po u\u017eit\u00ed antihistaminik se d\u00edky tomu c\u00edt\u00edme l\u00e9pe. Nicm\u00e9n\u011b, histamin bude st\u00e1le p\u0159\u00edtomen v na\u0161em t\u011ble a t\u011blo ho nad\u00e1le produkuje. Histamin se m\u016f\u017ee v\u00e1zat na jin\u00e9 histaminov\u00e9 receptory &#8211; H3 a H4 receptory (kter\u00e9 nejsou blokov\u00e1ny). To znamen\u00e1, \u017ee se st\u00e1le mohou vyskytnout p\u0159\u00edznaky spojen\u00e9 s t\u011bmito receptory.<\/p>\n<h3>Antihistaminika dostupn\u00e1 u n\u00e1s (SEZNAM)<\/h3>\n<div class='erit-product-small-box erit-float-right '>\n                <div class='erit-product-small-box-header'>\n                  <div class='erit-product-small-box-name'>\n                   <a href='https:\/\/zdravovek.eu\/a\/cs\/zodac-10-mg-10-tablet-drmax-cz\/' class='eap_conversion product_small_box product_name' rel='nofollow' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_product_small_box', 'EAP_click_product_name', null)\">Zodac 10 mg<\/a>\n                  <\/div>\n                  <div class='erit-product-small-box-desc'>10 tablet<\/div>\n                <\/div>\n\n                <div class='erit-product-small-box-row-wrap'>\n                  <div class='erit-product-small-box-img_wrap'>\n                    <a href='https:\/\/zdravovek.eu\/a\/cs\/zodac-10-mg-10-tablet-drmax-cz\/' class='eap_conversion product_small_box image' rel='nofollow' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_product_small_box', 'EAP_click_image', null)\">\n                      <img width='150' src='' alt='Zodac 10 mg'\/>\n                    <\/a>\n                  <\/div>\n\n                  <div class='erit-product-small-box-right-wrap'>\n                   <div class='erit-product-small-box-buttons'><a class='erit-product-small-box-review-button erit-small-button' href='https:\/\/zdravovek.eu\/cs\/zodac-antihistaminikum\/'  onclick=\"eap_add_gtm_event('EAP_interaction_product_small_box', 'EAP_click_review_button', null)\">\n                        Recenze\n                      <\/a><a class='erit-product-small-box-shop-button eap_conversion product_small_box cta_button erit-small-button' href='https:\/\/zdravovek.eu\/a\/cs\/zodac-10-mg-10-tablet-drmax-cz\/' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_product_small_box', 'EAP_click_cta_button', null)\">\n                          Do obchodu\n                      <\/a>\n                    <\/div>\n                    <div class='erit-product-small-box-price'>\n                      75&nbsp;K\u010d\n                    <\/div>\n                    <div class='erit-product-small-box-free-shipping erit-small'>\n                      Doprava zdarma od 999&nbsp;K\u010d\n                    <\/div>\n                  <\/div>\n                <\/div>\n              <\/div><strong>Antihistaminika prvn\u00ed generace<\/strong><\/p>\n<ul>\n<li>antazolin [Sanorin &#8211; analergin]<\/li>\n<li>moxastin [THEADRYL, KINEDRYL]<\/li>\n<li>emram\u00edn [Medrin]<\/li>\n<li>klemast\u00edn [Tavegyl]<\/li>\n<li>dimetinden [Fenistil]<\/li>\n<li>prometiaz\u00edn [Prothazin]<\/li>\n<li>bizulep\u00edn [DITHIADEN]<\/li>\n<li>ketotifen [Zaditen]<\/li>\n<li>azelastin [Allergodil]<\/li>\n<li>difenhydramin [CALMABEN]<\/li>\n<\/ul>\n<p><strong>Antihistaminika druh\u00e9 generace<\/strong><\/p>\n<ul>\n<li>astemizol [Hismanal]<\/li>\n<li>terfenadin [LOTANAX]<\/li>\n<li>ebast\u00edn [KESTINE]<\/li>\n<li>levokabastin [LIVOSTIN]<\/li>\n<li>cetirizin [ZYRTEC, Zodac, ALERID]<\/li>\n<li>loratadin [Claritine, Flonidan, CLARINASE]<\/li>\n<\/ul>\n<p><strong>Antihistaminika t\u0159et\u00ed generace<\/strong><\/p>\n<ul>\n<li>fexofenadin [fixi]<\/li>\n<li>desloratat\u00edn [AERIUS, desloratadin ZENTIVA]<\/li>\n<li>levocetirizin [Cezera, levocetirizin Teva, XYZAL, Zenari]<\/li>\n<\/ul>\n<h3>Voln\u011b prodejn\u00e1 antihistaminika<\/h3>\n<div class=\"erit-block erit-block-interesting\">\n<p><strong>Antihistaminika bez p\u0159edpisu<\/strong><\/p>\n<p>V \u010cesku jsou <strong>antihistaminika bez p\u0159edpisu<\/strong> dostupn\u00e1 pouze v balen\u00edch po 7, maxim\u00e1ln\u011b 10 ks. Pokud jich pot\u0159ebujete v\u00edce, budete muset nav\u0161t\u00edvit l\u00e9ka\u0159e, kter\u00fd je m\u016f\u017ee p\u0159edepsat ve v\u011bt\u0161\u00edm mno\u017estv\u00ed.<\/p>\n<p><strong>Voln\u011b prodejn\u00e1 antihistaminika jsou tato<\/strong>:<\/p>\n<ul>\n<li><strong><a href='https:\/\/zdravovek.eu\/a\/cs\/claritine-10-tablet-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">Claritine<\/a><\/strong> tablety 10 mg (loratadin) 10 ks &#8211; Cena: <a href='https:\/\/zdravovek.eu\/a\/cs\/claritine-10-tablet-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">95 K\u010d<\/a><\/li>\n<li><strong>Levocetirizin Dr.Max<\/strong> tablety 5 mg (levocetirizin) 10 ks &#8211; Cena: 79 K\u010d<\/li>\n<li><strong><a href='https:\/\/zdravovek.eu\/a\/cs\/xyzal-7-tablet-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">Xyzal<\/a><\/strong> tablety 5 mg (levocetirizin) 7 ks &#8211; Cena: <a href='https:\/\/zdravovek.eu\/a\/cs\/xyzal-7-tablet-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">90 K\u010d<\/a><\/li>\n<li><strong><a href='https:\/\/zdravovek.eu\/a\/cs\/zodac-10-mg-10-tablet-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">ZODAC<\/a><\/strong> tablety 10 mg (cetirizin) 7 ks &#8211; Cena: <a href='https:\/\/zdravovek.eu\/a\/cs\/zodac-10-mg-10-tablet-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">82 K\u010d<\/a><\/li>\n<li><strong><a href='https:\/\/zdravovek.eu\/a\/cs\/zyrtec-7-tablet-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">Zyrtec<\/a><\/strong> tablety 10 mg (cetirizin) 7 ks &#8211; Cena: <a href='https:\/\/zdravovek.eu\/a\/cs\/zyrtec-7-tablet-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">110 K\u010d<\/a><\/li>\n<\/ul>\n<\/div>\n<h2>Histaminov\u00e9 receptory a jejich funkce<\/h2>\n<p>Zn\u00e1me <strong>4 typy<\/strong> histaminov\u00fdch receptor\u016f &#8211; H1, H2, H3 a H4.<\/p>\n<p>Histaminov\u00e9 receptory se nach\u00e1zej\u00ed <strong>v r\u016fzn\u00fdch \u010d\u00e1stech t\u011bla<\/strong> a ka\u017ed\u00fd z nich m\u00e1 svou funkci. V\u00e1\u017eou se s histaminem na dosa\u017een\u00ed specifick\u00e9ho \u00fa\u010dinku na organismus. To, se kter\u00fdm bude histamin reagovat, z\u00e1vis\u00ed na tom, kde v t\u011ble se uvol\u0148uje.<\/p>\n<p><strong>Funkce receptor\u016f<\/strong>:<\/p>\n<ul>\n<li><strong>H1<\/strong>: Kdy\u017e se histamin v\u00e1\u017ee s t\u00edmto typem receptor\u016f, vytv\u00e1\u0159\u00ed p\u0159\u00edznaky typick\u00e9 pro alergii, jako: sv\u011bd\u011bn\u00ed (dr\u00e1\u017ed\u011bn\u00ed nociceptivn\u00edch nervov\u00fdch vl\u00e1ken), bolest, kop\u0159ivka, z\u00fa\u017een\u00ed d\u00fdchac\u00edch cest, kontrakce tenk\u00e9ho st\u0159eva (m\u016f\u017ee zp\u016fsobit a\u017e pr\u016fjem), pokles tlaku krve nebo zv\u00fd\u0161en\u00e1 tepov\u00e1 frekvence. H1 receptory jsou tak\u00e9 odpov\u011bdn\u00e9 za regulaci cirkadi\u00e1nn\u00edho cyklu (tj sp\u00e1nkov\u00fd cyklus). Zvy\u0161uj\u00ed ostra\u017eitost, a i proto jsou antihistaminika (kter\u00e9 blokuj\u00ed tento receptor) spojen\u00e1 s ospalost\u00ed.<\/li>\n<li><strong>H2<\/strong>: Interakce histaminu s t\u011bmito receptory zp\u016fsobuje produkci \u017ealude\u010dn\u00ed kyseliny (HCl), v men\u0161\u00ed m\u00ed\u0159e i pepsinu. Tak\u00e9 podporuj\u00ed relaxaci hladk\u00e9ho svalstva, blokuj\u00ed synt\u00e9zu protil\u00e1tek a staraj\u00ed se o vazodilataci (roz\u0161i\u0159uj\u00ed krevn\u00ed c\u00e9vy).<\/li>\n<li><strong>H3<\/strong>: Kdy\u017e se histamin v\u00e1\u017ee s t\u011bmito receptory, ovliv\u0148uje n\u00e1\u0161 centr\u00e1ln\u00ed nervov\u00fd syst\u00e9m (mozek a m\u00edchu). Zp\u016fsobuje sn\u00ed\u017een\u00ed produkce n\u011bkter\u00fdch neurotransmiter\u016f (konkr\u00e9tn\u011b acetylcholinu, serotoninu a noradrenalinu).<\/li>\n<li><strong>H4<\/strong>: Tyto receptory jsou ur\u010deny k regulaci imunitn\u00ed odpov\u011bdi. Staraj\u00ed se o odpov\u011b\u010f organismu na z\u00e1n\u011bt a usm\u011brn\u011bn\u00ed \u017e\u00edrn\u00fdch bun\u011bk na m\u00edsto z\u00e1n\u011btu.<\/li>\n<\/ul>\n<figure id=\"attachment_11335\" aria-describedby=\"caption-attachment-11335\" style=\"width: 1280px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" class=\"wp-image-11335 size-full\" src=\"https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory.jpg\" alt=\"Histaminov\u00e9 receptory\" width=\"1280\" height=\"937\" srcset=\"https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory.jpg 1280w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-600x439.jpg 600w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-300x220.jpg 300w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-768x562.jpg 768w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-1024x750.jpg 1024w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-80x60.jpg 80w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-696x509.jpg 696w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-1068x782.jpg 1068w, https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/04\/histaminove-receptory-574x420.jpg 574w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/><figcaption id=\"caption-attachment-11335\" class=\"wp-caption-text\">Zdroj: 123rf.com<\/figcaption><\/figure>\n<p>Kdy\u017e te\u010f zn\u00e1me <strong>funkce jednotliv\u00fdch receptor\u016f<\/strong>, snadn\u011bji se n\u00e1m bude ch\u00e1pat v\u00fdznam a p\u016fsoben\u00ed antihistaminik.<\/p>\n<p>V\u011bt\u0161ina antihistaminik p\u016fsob\u00ed na <strong>receptory H1 a H2<\/strong>. Zabra\u0148uj\u00ed histaminu, aby se na n\u011b nav\u00e1zal.<\/p>\n<p>Vzhledem k tomu, \u017ee antihistaminika neovliv\u0148uj\u00ed \u00fa\u010dinek histaminu na receptory H3 a H4, lid\u00e9, kte\u0159\u00ed je u\u017e\u00edvaj\u00ed, mohou m\u00edt <strong>probl\u00e9my s n\u00e1ladou<\/strong>, jako je deprese (v\u00edce o <a href=\"https:\/\/zdravovek.eu\/histamin-vplyv-na-naladu-a-zdravie\/\">vlivu histaminu na na\u0161i n\u00e1ladu se do\u010dtete zde<\/a>).<\/p>\n<p>Dal\u0161\u00ed v\u011bc, kterou je t\u0159eba zv\u00e1\u017eit, je, \u017ee n\u011bkter\u00e1 antihistaminika ovliv\u0148uj\u00ed schopnost na\u0161eho t\u011bla produkovat DAO enzym, kter\u00fd pom\u00e1h\u00e1 rozlo\u017eit histamin.<\/p>\n<div class=\"erit-block erit-block-interesting\">\n<p><strong>Vliv antihistaminik na sp\u00e1nek<\/strong><\/p>\n<p>Pod\u00e1v\u00e1n\u00ed antagonist\u016f H1 receptor\u016f (kter\u00fdmi jsou antihistaminika) podporuje sp\u00e1nek. Receptor H3 funguje jako autoreceptor (to znamen\u00e1, \u017ee s\u00e1m reguluje svou aktivitu) a reguluje synt\u00e9zu a uvol\u0148ov\u00e1n\u00ed histaminu. Aktivace receptor\u016f H3 sni\u017euje uvol\u0148ov\u00e1n\u00ed histaminu a podporuje sp\u00e1nek. Naopak, blokov\u00e1n\u00ed receptoru H3 podporuje bd\u011blost. Uvol\u0148ov\u00e1n\u00ed histaminu v hypotalamu a jin\u00fdch c\u00edlov\u00fdch oblastech je nejvy\u0161\u0161\u00ed b\u011bhem bd\u011blosti.<\/p>\n<\/div>\n<h3>H2 antihistaminika<\/h3>\n<p>B\u011b\u017en\u011b se term\u00edn &#8222;antihistaminikum&#8220; vztahuje pouze na H1-antihistaminika.<\/p>\n<p>Zn\u00e1me v\u0161ak i H2 antihistaminika, kter\u00e1 maj\u00ed odli\u0161nou \u00falohu (nevyu\u017e\u00edvaj\u00ed se p\u0159i l\u00e9\u010db\u011b alergi\u00ed). Selektivn\u011b\u00a0<strong>blokuj\u00ed H2-receptory<\/strong>, kter\u00e9 se nach\u00e1zej\u00ed <strong>v \u017ealudku<\/strong>. Tak zaji\u0161\u0165uj\u00ed sn\u00ed\u017eenou produkci \u017ealude\u010dn\u00edch \u0161\u0165\u00e1v (zejm\u00e9na HCl).<\/p>\n<p>Nepronikaj\u00ed do CNS (centr\u00e1ln\u00ed nervov\u00e9 soustavy), a tud\u00ed\u017e nevykazuj\u00ed centr\u00e1ln\u011b ne\u017e\u00e1douc\u00ed \u00fa\u010dinky. Pacienty jsou celkov\u011b <strong>dob\u0159e tolerov\u00e1ny<\/strong>. Cimetidin m\u00e1 z nich nejv\u00edce ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f a interakc\u00ed (proto\u017ee pat\u0159\u00ed mezi inhibitory CYP450).<\/p>\n<p>Z\u00e1stupci:<\/p>\n<ul>\n<li>cimetidin [cimetidin, BELOMET]<\/li>\n<li>ranitidin [Ranital, Ulcosan, Zantac]<\/li>\n<li>famotidin [QUAMATEL, FAMOSAN]<\/li>\n<li>nizatid\u00edn<\/li>\n<\/ul>\n<p>Pou\u017eit\u00ed:<\/p>\n<ul>\n<li>stavy spojen\u00e9 se <strong>zv\u00fd\u0161enou tvorbou<\/strong> \u017ealude\u010dn\u00ed <strong>kyseliny<\/strong><\/li>\n<li><a href=\"https:\/\/zdravovek.eu\/zaludocne-vredy\/\"><strong>\u017ealude\u010dn\u00ed v\u0159edy<\/strong><\/a>, dvan\u00e1ctn\u00edkov\u00e9 v\u0159edy<\/li>\n<li>gastroezofage\u00e1ln\u00ed <strong>reflux<\/strong> (m\u016f\u017ee se projevovat <a href=\"https:\/\/zdravovek.eu\/palenie-zahy\/\">p\u00e1len\u00edm \u017e\u00e1hy<\/a>)<\/li>\n<li>Zollinger-Ellison\u016fv syndrom<\/li>\n<\/ul>\n<h2>\u017d\u00edrn\u00e9 bu\u0148ky<\/h2>\n<p>\u017d\u00edrn\u00e9 bu\u0148ky <strong>uvol\u0148uj\u00ed histamin<\/strong>. Vedle histaminu z\u00e1rove\u0148 uvol\u0148uj\u00ed i <strong>serotonin<\/strong>, <strong>superoxid<\/strong> (zp\u016fsobuje ment\u00e1ln\u00ed mlhu, sni\u017euje tvorbu T3 &#8211; hormon \u0161t\u00edtn\u00e9 \u017el\u00e1zy), <strong>heparin<\/strong> (antikoagulant), <strong>trypt\u00e1zu<\/strong>, <strong>tromboxan<\/strong> (tvorba krevn\u00edch sra\u017eenin), <strong>PGD2<\/strong> (zp\u016fsobuje z\u00fa\u017een\u00ed d\u00fdchac\u00edch cest) a <strong>PAF<\/strong> (zp\u016fsobuje ateroskler\u00f3zu).<\/p>\n<p>\u017d\u00edrn\u00e9 bu\u0148ky jsou p\u0159\u00edtomny ve v\u011bt\u0161in\u011b tk\u00e1n\u00ed obklopuj\u00edc\u00edch krevn\u00ed c\u00e9vy a nervy. Jsou p\u0159\u00edtomny zejm\u00e9na v oblastech, kter\u00e9 interaguj\u00ed s vn\u011bj\u0161\u00edm sv\u011btem: k\u016f\u017e\u00ed, pl\u00edcemi, za\u017e\u00edvac\u00edm traktem, \u00fasty, v\u00ed\u010dky a nosem.<\/p>\n<h3>Stabiliz\u00e1tory \u017e\u00edrn\u00fdch bun\u011bk<\/h3>\n<p>Stabiliz\u00e1tory \u017e\u00edrn\u00fdch bun\u011bk &#8211; l\u00e9ky, kter\u00e9 <strong>zabra\u0148uj\u00ed uvol\u0148ov\u00e1n\u00ed histaminu<\/strong> a jin\u00fdch siln\u00fdch medi\u00e1tor\u016f ze \u017e\u00edrn\u00fdch bun\u011bk. \u017d\u00edrn\u00e9 bu\u0148ky jsou typem b\u00edl\u00fdch krvinek, kter\u00e9 jsou sou\u010d\u00e1st\u00ed na\u0161eho <strong>imunitn\u00edho syst\u00e9mu<\/strong>. Hraj\u00ed kl\u00ed\u010dovou roli v reakci na\u0161eho t\u011bla na antigeny (toxick\u00e1 nebo ciz\u00ed l\u00e1tka, kter\u00e1 je vn\u00edm\u00e1na jako hrozba pro na\u0161e t\u011blo, a kter\u00e1 vyvol\u00e1v\u00e1 imunitn\u00ed odpov\u011b\u010f).<\/p>\n<p>Aktivace \u017e\u00edrn\u00fdch bun\u011bk hraje \u00fast\u0159edn\u00ed roli p\u0159i projevech jako:<\/p>\n<ul>\n<li>alergick\u00e1 r\u00fdma a alergick\u00e1 konjunktivitida<\/li>\n<li>anafylaxe<\/li>\n<li>astma<\/li>\n<li>autoimunitn\u00ed onemocn\u011bn\u00ed<\/li>\n<li>ekz\u00e9m, kop\u0159ivka a sv\u011bd\u011bn\u00ed<\/li>\n<li>a reproduk\u010dn\u00ed poruchy (potla\u010duj\u00ed plodnost a pohyblivost spermi\u00ed u mu\u017e\u016f)<\/li>\n<\/ul>\n<p>Nejzn\u00e1m\u011bj\u0161\u00ed stabiliz\u00e1tory \u017e\u00edrn\u00fdch bun\u011bk se naz\u00fdvaj\u00ed kromony. Pat\u0159\u00ed mezi n\u011b <strong>kromoglykan sodn\u00fd<\/strong> (dihydr\u00e1t cromoglicas) a <strong>nedokromil<\/strong>. P\u016fsob\u00ed blokov\u00e1n\u00edm v\u00e1pn\u00edkov\u00e9ho kan\u00e1lu, kter\u00fd je nezbytn\u00fd pro degranulaci \u017e\u00edrn\u00fdch bun\u011bk (uvoln\u011bn\u00ed chemick\u00fdch medi\u00e1tor\u016f). Pod\u00e1vaj\u00ed se inhala\u010dn\u011b. U\u017e\u00edvaj\u00ed se p\u0159i alergick\u00fdch onemocn\u011bn\u00edch d\u00fdchac\u00edch cest (nap\u0159. Astma).<\/p>\n<div class=\"erit-block erit-block-interesting\">\n<p><strong>Shrnut\u00ed<\/strong>:<\/p>\n<p>Histamin je uvol\u0148ov\u00e1n imunitn\u00edmi bu\u0148kami naz\u00fdvan\u00fdmi \u017e\u00edrn\u00e9 bu\u0148ky. Kdy\u017e dos\u00e1hneme stabilizace t\u011bchto bun\u011bk, histamin se neuvoln\u00ed.<\/p>\n<p>Pokud jsou \u017e\u00edrn\u00e9 bu\u0148ky aktivov\u00e1ny, doch\u00e1z\u00ed k uvoln\u011bn\u00ed i jin\u00fdch l\u00e1tek krom\u011b histaminu (vyjmenovan\u00fdch v\u00fd\u0161e).<\/p>\n<\/div>\n<h3>P\u0159\u00edrodn\u00ed &#8222;antihistaminika&#8220;<\/h3>\n<p>N\u011bkter\u00e9 p\u0159\u00edrodn\u00ed l\u00e1tky pat\u0159\u00ed mezi stabiliz\u00e1tory \u017e\u00edrn\u00fdch bun\u011bk, a proto <strong>zabra\u0148uj\u00ed uvol\u0148ov\u00e1n\u00ed histaminu<\/strong>. Pat\u0159\u00ed sem hlavn\u011b rostlinn\u00e9 slo\u017eky jako flavonoidy, kumariny, \u010di fenoly.<\/p>\n<div class='erit-product-small-box erit-float-right '>\n                <div class='erit-product-small-box-header'>\n                  <div class='erit-product-small-box-name'>\n                   <a href='https:\/\/zdravovek.eu\/a\/cs\/kvercetin-epigemic-90-kapsli-prozdravi-cz\/' class='eap_conversion product_small_box product_name' rel='nofollow' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_product_small_box', 'EAP_click_product_name', null)\">Kvercetin Epigemic<\/a>\n                  <\/div>\n                  <div class='erit-product-small-box-desc'>90 kapsl\u00ed<\/div>\n                <\/div>\n\n                <div class='erit-product-small-box-row-wrap'>\n                  <div class='erit-product-small-box-img_wrap'>\n                    <a href='https:\/\/zdravovek.eu\/a\/cs\/kvercetin-epigemic-90-kapsli-prozdravi-cz\/' class='eap_conversion product_small_box image' rel='nofollow' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_product_small_box', 'EAP_click_image', null)\">\n                      <img width='150' src='https:\/\/zdravovek.eu\/wp-content\/uploads\/2018\/05\/n-a-e1546599367999.jpg' alt='Kvercetin Epigemic'\/>\n                    <\/a>\n                  <\/div>\n\n                  <div class='erit-product-small-box-right-wrap'>\n                   <div class='erit-product-small-box-buttons'><a class='erit-product-small-box-shop-button eap_conversion product_small_box cta_button ' href='https:\/\/zdravovek.eu\/a\/cs\/kvercetin-epigemic-90-kapsli-prozdravi-cz\/' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_product_small_box', 'EAP_click_cta_button', null)\">\n                          Do obchodu\n                      <\/a>\n                    <\/div>\n                    <div class='erit-product-small-box-price'>\n                      490&nbsp;K\u010d\n                    <\/div>\n                    <div class='erit-product-small-box-free-shipping erit-small'>\n                      Doprava zdarma od 999&nbsp;K\u010d\n                    <\/div>\n                  <\/div>\n                <\/div>\n              <\/div><strong>P\u0159\u00edrodn\u00ed l\u00e1tky<\/strong> stabilizuj\u00edc\u00ed \u017e\u00edrn\u00e9 bu\u0148ky:<\/p>\n<ul>\n<li><strong><a href='https:\/\/zdravovek.eu\/a\/cs\/kvercetin-epigemic-90-kapsli-prozdravi-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">kvercetin<\/a><\/strong> &#8211; funguje l\u00e9pe ne\u017e prevence<\/li>\n<li><strong><a href='https:\/\/zdravovek.eu\/a\/cs\/kurkumin-komplex-forte-60-kapsli-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">kurkumin<\/a><\/strong> (Pozor! Kurkumin sni\u017euje DAO)<\/li>\n<li>luteolin<\/li>\n<li>apigenin<\/li>\n<li>astragalus \/astragal\u00edn<\/li>\n<li><strong><a href='https:\/\/zdravovek.eu\/a\/cs\/terezia-bio-reishi-60-kapsli-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">Reishi<\/a><\/strong><\/li>\n<li><strong><a href='https:\/\/zdravovek.eu\/a\/cs\/eleuterokok-ostnity-bylinne-kapky-50-ml-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">Eleuthero<\/a><\/strong><\/li>\n<li>kempferol<\/li>\n<li>myricet\u00edn<\/li>\n<li>rutin<\/li>\n<li><a href='https:\/\/zdravovek.eu\/a\/cs\/l-theanin-30-tablet-prozdravi-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">theanin<\/a><\/li>\n<\/ul>\n<h2>Histaminov\u00e1 intolerance a antihistaminika<\/h2>\n<p>V p\u0159\u00edpad\u011b histaminov\u00e9 intolerance l\u00e9ka\u0159 \u010dasto p\u0159edep\u00ed\u0161e i antihistaminika.<\/p>\n<p><strong>P\u0159\u00edznaky<\/strong> HIT mohou b\u00fdt odstran\u011bny n\u00edzko-histaminovou dietou. Z\u00e1rove\u0148 v\u0161ak mohou b\u00fdt <strong>zm\u00edrn\u011bny i antihistaminiky<\/strong>.<\/p>\n<p>V\u011bt\u0161ina antihistaminik nem\u00e1 \u017e\u00e1dn\u00fd vliv na aktivitu DAO.<\/p>\n<p>L\u00e9\u010diva jako <strong>cimetidin a dihydralazin mohou inhibovat aktivitu enzymu DAO<\/strong>. Naopak, p\u0159i u\u017e\u00edv\u00e1n\u00ed difenhydraminu byla pozorov\u00e1na zv\u00fd\u0161en\u00e1 aktivita diaminooxid\u00e1zy (zdroj: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9831324\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed<\/a>).<\/p>\n<span class=\"erit-highlight\">V p\u0159\u00edpad\u011b, \u017ee dodr\u017eujete striktn\u00ed n\u00edzko-histaminovou dietu, u\u017e\u00edv\u00e1n\u00ed antihistaminik zpravidla nen\u00ed nutn\u00e9.<\/span>\n<h3>L\u00e9ky a v\u00fd\u017eivov\u00e9 dopl\u0148ky na sn\u00ed\u017een\u00ed hladin histaminu<\/h3>\n<p>Degradace histaminu m\u016f\u017ee b\u00fdt podpo\u0159ena u\u017e\u00edv\u00e1n\u00edm <strong><a href='https:\/\/zdravovek.eu\/a\/cs\/jamieson-vitamin-c-1000mg-120-tablet-benu-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">vitam\u00ednu C<\/a><\/strong> a <strong><a href='https:\/\/zdravovek.eu\/a\/cs\/magne-b6-forte-50-tablet-pilulka-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">vitam\u00ednu B6<\/a><\/strong>, co\u017e vede ke zv\u00fd\u0161en\u00ed aktivity DAO.<\/p>\n<p>Pozitivn\u00ed \u00fa\u010dinky byly hl\u00e1\u0161eny i u stabiliz\u00e1tor\u016f \u017e\u00edrn\u00fdch bun\u011bk a pankreatick\u00fdch enzym\u016f (nap\u0159\u00edklad l\u00e9k\u00a0<strong><a href='https:\/\/zdravovek.eu\/a\/cs\/pancreolan-forte-60-kapsli-drmax-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">Pancreolan FORTE<\/a><\/strong>). Jejich u\u017e\u00edv\u00e1n\u00ed bylo v\u00fdhodn\u00e9 zejm\u00e9na u pacient\u016f, kte\u0159\u00ed m\u011bli gastrointestin\u00e1ln\u00ed symptomy (za\u017e\u00edvac\u00ed pot\u00ed\u017ee).<\/p>\n<p>Pacienti maj\u00ed pozitivn\u00ed zku\u0161enosti i s <strong><a href='https:\/\/zdravovek.eu\/a\/cs\/daosin-30-tobolek-pilulka-cz\/' class='eap_conversion affil_link' rel='nofollow noopener' target='_blank'  onclick=\"eap_add_gtm_event('EAP_conversion_affil_link_a', 'EAP_click_affil_link_a', null)\">kapslemi s obsahem DAO<\/a><\/strong>. Slou\u017e\u00ed k dopln\u011bn\u00ed nedostatku DAO u pacient\u016f s histaminovou intoleranc\u00ed. P\u0159\u00edpravek Daosin je pacienty velmi dob\u0159e sn\u00e1\u0161en. Tato <a href=\"https:\/\/zdravovek.eu\/daosin\/\">recenze na p\u0159\u00edpravek Daosin<\/a> v\u00e1m poskytne v\u00edce informac\u00ed.<\/p>\n<p>U\u017e\u00edv\u00e1n\u00ed n\u011bkter\u00fdch l\u00e9k\u016f m\u016f\u017ee vyvolat reakce u pacient\u016f s HIT (o kter\u00e9 l\u00e9ky se jedn\u00e1, se do\u010dtete bl\u00ed\u017ee v p\u0159\u00edru\u010dce <a href=\"https:\/\/zdravovek.eu\/histaminova-intolerancia\/#Lieky\">histaminovou intoleranc\u00ed<\/a>). Pokud m\u00e1te podez\u0159en\u00ed na HIT, m\u011bli byste se u\u017e\u00edv\u00e1n\u00ed t\u011bchto l\u00e9k\u016f vyhnout. Pokud je pod\u00e1v\u00e1n\u00ed t\u011bchto l\u00e9k\u016f nezbytn\u00e9, v tom p\u0159\u00edpad\u011b se doporu\u010duje p\u0159edchoz\u00ed l\u00e9\u010dba antihistaminiky.<\/p>\n<div class='erit-toggle-block'>\n      <input type='checkbox' id='erit-toggle-block-checkbox-e9jyp9' class='erit-toggle-block-checkbox'\/>\n                  <label for='erit-toggle-block-checkbox-e9jyp9' class='erit-toggle-block-header'>Zdroje:<\/label>\n                  <div class='erit-toggle-block-content'>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20851648\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed<\/a> &#8211; Histamin p\u0159i regulaci bd\u011blosti<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9831324\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">PubMed<\/a> &#8211; vliv antihistaminik na s\u00e9rov\u00e9 hladiny DAO<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3764846\/\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">PubMed<\/a> &#8211; stabiliz\u00e1tory \u017e\u00edrn\u00fdch bun\u011bk<\/li>\n<li><a href=\"https:\/\/www.drugs.com\/drug-class\/antihistamines.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Drugs.com<\/a><\/li>\n<li><a href=\"https:\/\/academic.oup.com\/ajcn\/article\/85\/5\/1185\/4633007\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">academic<\/a><\/li>\n<li><a href=\"https:\/\/hollywoodhomestead.com\/antihistamines-histamine-intolerance\/\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">hollywoodhomestead<\/a><\/li>\n<li><a href=\"https:\/\/www.selfhacked.com\/blog\/deal-histamine\/#Histamine_and_Mast_Cell_Stabilizers\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">selfhacked<\/a><\/li>\n<li><a href=\"https:\/\/www.mommypotamus.com\/histamine-intolerance\/\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">mommypotamus<\/a><\/li>\n<\/ul>\n<\/div>\n              <\/div>\n<div class='erit-disclaimer'><span class='erit-disclaimer-icon'><span class='erit-disclaimer-text'>!<\/span><\/span><span class='erit-disclaimer-text'>\u010cl\u00e1nek byl vypracov\u00e1n l\u00e9k\u00e1rn\u00edkem av\u0161ak, slou\u017e\u00ed pouze pro informativn\u00ed \u00fa\u010dely - nenahrazuje l\u00e9ka\u0159sk\u00e9 vy\u0161et\u0159en\u00ed, nebo osobn\u00ed setk\u00e1n\u00ed v l\u00e9k\u00e1rn\u011b.<\/span><\/div>\n<script type='text\/javascript' >\n                jQuery(document).ready(function($) {\n    \n                    let data = {\n                        'action': 'render_widget_action',\n                        'postId': null,\n                        'categoryId': null\n                    };\n    \n                    let ajaxUrlFromPHP = 'https:\/\/zdravovek.eu\/wp-admin\/admin-ajax.php';\n                    jQuery.post(ajaxUrlFromPHP, data, function(response) {\n                        if(response == 0){\n                            \/\/ chyba\n                            jQuery( '#eap_top_w' ).html( '' );\n                            jQuery( '#eap_top_w_wrap' ).hide();\n                        } if(response == -1){\n                            \/\/ nenasli ziadne produkty\n                            jQuery( '#eap_top_w' ).html( '' );\n                            jQuery( '#eap_top_w_wrap' ).hide();\n                        } else {\n                            let desktop = $(window).width() > 960;\n                            if(desktop){\n                                jQuery( '#eap_top_w' ).html( response );\n                                jQuery( '#eap_top_w_wrap' ).fadeIn(1000);\n                            } else {\n                                jQuery( '#eap_top_w_mob_chart' ).html( response );\n                                jQuery( '#eap_top_w_mob' ).fadeIn(1000); 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Ale v\u00edte, na co v\u0161echno se je\u0161t\u011b mohou vyu\u017e\u00edt? Zn\u00e1me n\u011bkolik druh\u016f, kter\u00e9 mohou fungovat rozd\u00edln\u011b &#8211; podle toho, na jak\u00fd histaminov\u00fd receptor se v\u00e1\u017eou. Sepsali jsme seznam\u00a0antihistaminik, podle toho, do kter\u00e9 generace pat\u0159\u00ed + kter\u00e1 antihistaminika dostanete bez p\u0159edpisu. Zjist\u00edte tak\u00e9, kter\u00e9 p\u0159\u00edrodn\u00ed [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":10131,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[81,79],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Antihistaminika - jak\u00e9 druhy zn\u00e1me, jejich \u00fa\u010dinky, pou\u017eit\u00ed | Zdravov\u011bk<\/title>\n<meta name=\"description\" content=\"Antihistaminika jsou l\u00e9ky, kter\u00e9 se v\u011bt\u0161inou pou\u017e\u00edvaj\u00ed na alergii. Ale jak vlastn\u011b funguj\u00ed? 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