{"id":7120,"date":"2018-07-15T12:40:54","date_gmt":"2018-07-15T10:40:54","guid":{"rendered":"https:\/\/zdravovek.eu\/?p=7120"},"modified":"2020-09-15T18:58:17","modified_gmt":"2020-09-15T16:58:17","slug":"histaminova-intolerance-leky","status":"publish","type":"post","link":"https:\/\/zdravovek.eu\/cs\/histaminova-intolerance-leky\/","title":{"rendered":"Histaminov\u00e1 intolerance – l\u00e9ky a v\u00fd\u017eivov\u00e9 dopl\u0148ky"},"content":{"rendered":"

V\u00edte, jak\u00e9 jsou vhodn\u00e9 l\u00e9ky a alternativn\u00ed l\u00e9\u010dba<\/strong> ke zm\u00edrn\u011bn\u00ed p\u0159\u00edznak\u016f histaminov\u00e9 intolerance?<\/p>\n

P\u0159i HIT je nejd\u016fle\u017eit\u011bj\u0161\u00ed dieta<\/strong> s omezen\u00fdm p\u0159\u00edjmem histaminu v potrav\u011b. T\u00edm se sn\u00ed\u017e\u00ed celkov\u00e1 hladina histaminu v t\u011ble. V mnoha p\u0159\u00edpadech to posta\u010duje na sn\u00ed\u017een\u00ed symptom\u016f citlivosti na histamin.<\/p>\n

Pokud dieta nezabere, l\u00e9ka\u0159 v\u00e1m m\u016f\u017ee p\u0159edepsat l\u00e9ky nebo si m\u016f\u017eete pomoci n\u011bkter\u00fdmi dopl\u0148ky v\u00fd\u017eivy.<\/p>\n\n

L\u00e9ky<\/h2>\n

Nej\u010dast\u011bji se p\u0159edepisuj\u00ed n\u011bkter\u00e9 z n\u00e1sleduj\u00edc\u00edch l\u00e9k\u016f:<\/p>\n

Antihistaminika<\/h3>\n

Pou\u017eit\u00ed<\/strong>: Pro pacienty s HIT jako prevence z\u00e1va\u017en\u00fdch alergick\u00fdch reakc\u00ed (nap\u0159. Anafylaktick\u00fd \u0161ok apod.). Pozor, antihistaminika zm\u00edr\u0148uj\u00ed jen p\u0159\u00edznaky<\/strong> – nepostaraj\u00ed se o degradaci histaminu v t\u011ble.<\/p>\n

Jak funguj\u00ed?<\/h4>\n

Mechanismus<\/strong>: Antihistaminika sni\u017euj\u00ed nep\u0159\u00edjemn\u00e9 \u00fa\u010dinky histaminu p\u0159i alergi\u00edch a z\u00e1n\u011btech. Tyto l\u00e9ky br\u00e1n\u00ed vazb\u011b histaminu na H1 receptory<\/strong> (ne\u00fa\u010dinkuj\u00ed na H2, H3 a H4 receptory). Z\u00e1rove\u0148 funguj\u00ed i jako inverzn\u00ed agonist\u00e9 – stabilizuj\u00ed neaktivn\u00ed formu tohoto receptoru. Blokov\u00e1n\u00edm receptor\u016f zabra\u0148uj\u00ed vnik\u00e1n\u00ed histaminu do bu\u0148ky.<\/p>\n

Tvar aktivn\u00ed molekuly antihistaminika napodobuje \u010d\u00e1st histaminu, kter\u00e1 se v\u00e1\u017ee na receptor.<\/p>\n

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Chcete v\u011bd\u011bt, jak vlastn\u011b funguj\u00ed antihistaminika<\/a>? Doporu\u010dujeme v\u00e1m p\u0159e\u010d\u00edst si \u010dl\u00e1nek, kde vysv\u011btlujeme, jak\u00e9 jsou rozd\u00edly<\/strong> mezi jednotliv\u00fdmi antihistaminiky, jak\u00e9 maj\u00ed \u00fa\u010dinky<\/strong> a kter\u00e9 jsou dostupn\u00e9 bez p\u0159edpisu<\/strong>\u00a0(+ jejich vliv na HIT<\/strong>).<\/p>\n<\/div>\n

Mechanismus m\u016f\u017eeme p\u0159irovnat ke kl\u00ed\u010di a z\u00e1mku:<\/p>\n

Antihistaminikum je kl\u00ed\u010d ve stejn\u00e9m tvaru jako histamin. Oba kl\u00ed\u010de zapadaj\u00ed do z\u00e1mku, ale pouze histamin je schopen „odemknout funkci bu\u0148ky“. Antihistaminikum se sice do z\u00e1mku dostane, ale neodemkne ji (a tedy histamin nepronikne do bu\u0148ky).<\/p>\n

U\u017e\u00edv\u00e1n\u00ed antihistaminik tedy p\u0159i l\u00e9\u010db\u011b alergie nebo z\u00e1n\u011btu zabr\u00e1n\u00ed histaminu dostat se do posti\u017een\u00fdch bun\u011bk. T\u00edm do\u010dasn\u011b zm\u00edrn\u00ed nebo \u00fapln\u011b odstran\u00ed p\u0159\u00edznaky.<\/p>\n

Nicm\u00e9n\u011b, antihistaminika nezastavuj\u00ed uvol\u0148ov\u00e1n\u00ed histaminu ze \u017e\u00edrn\u00fdch bun\u011bk<\/strong> (mastocyt\u016f – tam doch\u00e1z\u00ed k jeho tvorb\u011b). Proto bude v t\u011ble cirkulovat stejn\u00e9 mno\u017estv\u00ed histaminu jako p\u0159ed u\u017eit\u00edm l\u00e9ku. Jeho funkce je zabr\u00e1n\u011bn\u00ed \u00fa\u010dink\u016f histaminu. Jakmile odezn\u00ed \u00fa\u010dinek l\u00e9ku, histamin se napoj\u00ed na dostupn\u00e9 receptory a dojde k projeven\u00ed p\u0159\u00edznak\u016f (zdroj: histamine-sensitivity<\/a>).<\/p>\n

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Shrnut\u00ed<\/strong>: Antihistaminika zastavuj\u00ed \u010dinnost histaminu pouze na tak dlouho, jak\u00e1 je jejich \u017eivotnost v t\u011ble (metabolismus + jejich eliminace). Kdy\u017e l\u00e9k ji\u017e nen\u00ed p\u0159\u00edtomen v mno\u017estv\u00ed dostate\u010dn\u00e9m k blokov\u00e1n\u00ed histaminov\u00fdch receptor\u016f, histamin op\u011bt zp\u016fsob\u00ed probl\u00e9my (proto\u017ee nedojde ke sn\u00ed\u017een\u00ed jeho hladiny). Pokud jste p\u0159ekro\u010dili hranici va\u0161\u00ed tolerance p\u0159ed u\u017eit\u00edm antihistaminika, bude po u\u017eit\u00ed l\u00e9ku + po vyprch\u00e1n\u00ed jeho \u00fa\u010dinku st\u00e1le nad hranic\u00ed tolerance.<\/p>\n<\/div>\n

Kortikoidy<\/h3>\n

Peror\u00e1ln\u00ed kortikosteroidy (nap\u0159. Prednison) jsou \u010dasto p\u0159edepisov\u00e1ny na kontrolu z\u00e1n\u011btliv\u00fdch stav\u016f<\/strong>. Kortikosteroidy jsou l\u00e9ky, kter\u00e9 potla\u010duj\u00ed imunitn\u00ed syst\u00e9m, v d\u016fsledku \u010deho\u017e nedoch\u00e1z\u00ed k uvol\u0148ov\u00e1n\u00ed medi\u00e1tor\u016f z\u00e1n\u011btu (v\u010detn\u011b histaminu). Medi\u00e1tory z\u00e1n\u011btu jsou zodpov\u011bdn\u00e9 za ne\u017e\u00e1douc\u00ed reakce.<\/p>\n

V p\u0159\u00edpad\u011b kop\u0159ivky (vyr\u00e1\u017eky) je uvol\u0148ov\u00e1n\u00ed histaminu t\u011bmito l\u00e9ky inhibov\u00e1no. Proto doch\u00e1z\u00ed k zabr\u00e1n\u011bn\u00ed projev\u016f p\u0159\u00edznak\u016f.<\/p>\n

Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed<\/strong> kortikosteroid\u016f je siln\u011b kontraindikov\u00e1no<\/strong>, proto jsou vhodn\u00e9 jin\u00e9 metody kontroly nadm\u011brn\u00e9ho mno\u017estv\u00ed histaminu v t\u011ble – nap\u0159\u00edklad antihistaminov\u00e1 dieta<\/strong><\/a>.<\/p>\n

Nicm\u00e9n\u011b, kortikoidy dok\u00e1\u017e\u00ed v n\u011bkter\u00fdch p\u0159\u00edpadech zachra\u0148ovat \u017eivot! Proto pokud m\u00e1te z\u00e1va\u017en\u00e9 reakce a l\u00e9ka\u0159 v\u00e1m je p\u0159edepsal, v\u017edy je u\u017e\u00edvejte podle doporu\u010den\u00ed.<\/p>\n

Alternativn\u00ed l\u00e9\u010dba<\/h2>\n

Z b\u011b\u017en\u011b dostupn\u00fdch dopl\u0148k\u016f v\u00fd\u017eivy v\u00e1m n\u011bkter\u00e9 mohou v\u00fdrazn\u011b pomoci ke zm\u00edrn\u011bn\u00ed p\u0159\u00edznak\u016f histaminov\u00e9 intolerance.<\/p>\n

Poj\u010fme se spolu pod\u00edvat na TOP 7 dopl\u0148k\u016f v\u00fd\u017eivy<\/strong>:<\/p>\n

Daosin<\/h3>\n

\"DAOSIN<\/a>Daosin<\/a><\/strong> – nej\u010dast\u011bji pou\u017e\u00edvan\u00fd v\u00fd\u017eivov\u00fd dopln\u011bk p\u0159i HIT. Obsahuje enzym DAO<\/strong> (diaminooxid\u00e1za), kter\u00fd v na\u0161em t\u011ble rozkl\u00e1d\u00e1 histamin.<\/p>\n

Je alternativou, pokud nem\u016f\u017eete (nebo nechcete) dr\u017eet elimina\u010dn\u00ed dietu. Daosin se u\u017e\u00edv\u00e1 p\u0159ed j\u00eddlem s obsahem histaminu<\/strong> a m\u016f\u017ee v\u00e1m pomoci p\u0159i p\u0159edch\u00e1zen\u00ed p\u0159\u00edznak\u016f. V\u00edce o Daosinu si m\u016f\u017eete nastudovat v t\u00e9to recenzi<\/a>.<\/p>\n

Probiotika<\/h3>\n

Probiotika<\/a><\/strong> jsou t\u011blu prosp\u011b\u0161n\u00e9 bakterie, kter\u00e9 m\u016f\u017eeme p\u0159ijmout z fermentovan\u00fdch potravin<\/strong>. Tento druh potravin je v\u0161ak pro n\u00e1s, histaminiky, p\u0159\u00edsn\u011b zak\u00e1z\u00e1n. Zb\u00fdv\u00e1 n\u00e1m tedy spolehnout se jen na probiotika v podob\u011b dopl\u0148k\u016f v\u00fd\u017eivy<\/strong>.<\/p>\n

Jedna studie zkoumala \u00fa\u010dinky n\u011bkolika probiotick\u00fdch kmen\u016f na lidsk\u00e9 \u017e\u00edrn\u00e9 bu\u0148ky. Sni\u017eovat uvol\u0148ov\u00e1n\u00ed histaminu<\/strong> byly schopny zejm\u00e9na dva kmeny:<\/p>\n

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  1. Lactobacillus rhamnosus<\/em> (konkr\u00e9tn\u011b GG a Lc705)<\/li>\n
  2. a Bifidobacterium animalis<\/em> ssp. lactis<\/em> Bb12 (zdroj: PubMed<\/a> ).<\/li>\n<\/ol>\n

    Mezi probiotika s jejich obsahem pat\u0159\u00ed nap\u0159\u00edklad: PROBIO-FIX Imun<\/a><\/strong> nebo Biopron FORTE<\/a><\/strong> (av\u0161ak Biopron FORTE obsahuje i kvasinku Saccharomyces boulardii<\/em> , jej\u00ed\u017e pou\u017eit\u00ed je p\u0159i HIT diskutabiln\u00ed).<\/p>\n

    N\u011bkter\u00fdm bakteri\u00e1ln\u00edm kmen\u016fm je t\u0159eba zabr\u00e1nit, proto\u017ee produkuj\u00ed biogenn\u00ed aminy. Mezi n\u011b pat\u0159\u00ed nap\u0159\u00edklad kmeny Lactobacillus casei<\/em> a Lactobacillus bulgaricus (<\/em>p\u0159e\u010dt\u011bte si \u010dl\u00e1nek a zjist\u00edte, co jsou to biogenn\u00ed aminy<\/a> a pro\u010d se jim p\u0159i HIT t\u0159eba vyh\u00fdbat).<\/p>\n

    Probiotika, kter\u00e1 ANO<\/strong>:<\/p>\n

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